Recently, cannabis, or its major constituent cannabidiol (CBD), has emerged as an attractive\ncosmetic ingredient. Initiated as a basic investigation of the physiological roles of cannabinoid\nreceptors and their endogenous ligands, endocannabinoidsâ?? diverse potential benefits have been\nproposed for using cannabinoid receptor modulating compounds in skin health. Improvement in skin\nbarrier functions, alleviating inflammatory responses, and the relief of itching sensations are some\ncommonly expected therapeutic benefits, which have been supported by many in vitro, in vivo, and\nclinical studies. While hemp seed oils or hemp extracts might be used for the cosmetic formulation,\nthe potential for contamination with a psychoactive cannabinoid, such as 9-THC, should be carefully\nchecked. Instead of using hemp-derived ingredients, the use of cannabinomimetics, synthetic ligands\non cannabinoid receptors, or entourage compounds (which modulate intracellular synthesis and\nthe degradation of endocannabinoids), have been tried. In this review, a brief introduction of the\nepidermal endocannabinoid system (EES) and its physiological roles will be followed by a review\nof the cosmetic and dermatologic application of cannabinomimetics and entourage compounds.\nThe practical application of newly developed endocannabinomimetics will be discussed as well.
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